ニチグルカン関連 論文

*出版物へのリンクは、教育目的のためにのみ掲載されています。

プリプリント掲載論文
6)
Raghavan K, Dedeepiya VD, Srinivasan S, Pushkala S, Subramanian S, Ikewaki N, Iwasaki M, Senthilkumar R, Preethy S, Abraham S. Disease-modifying immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in young boys with Duchenne muscular dystrophy: Results of an open-label, prospective, randomized, comparative clinical study.
Duchenne型筋ジストロフィーの少年におけるAureobasidium pullulans産の1,3-1,6βグルカンN-163株の疾患修飾免疫調節効果。非盲検前向き無作為化比較臨床試験結果
https://www.medrxiv.org/content/10.1101/2021.12.13.21267706v1

5)
Raghavan K, Dedeepiya VD, Yamamoto N, Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M,Kandaswamy R, Senthilkumar R, Preethy S, Abraham SJK. Beneficial reconstitution of gut microbiota and control of alpha-synuclein and curli-amyloids-producing enterobacteria, by beta 1,3-1,6 glucans in a clinical pilot study of autism and potentials in neurodegenerative diseases.
自閉症の臨床試験におけるβ1,3-1,6グルカンによる腸内細菌叢の再構成とαシヌクレインおよびカーリーアミロイド産生腸内細菌の制御、および神経変性疾患における可能性について
https://www.medrxiv.org/content/10.1101/2021.10.26.21265505v1

4)
Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M, Dedeepiya VD, Senthilkumar R, Preethy S, Abraham SJK. Immune and metabolic beneficial effects of Beta 1,3-1,6 glucans produced by two novel strains of Aureobasidium pullulans in healthy middle-aged Japanese men: An exploratory study.
健康な日本人中年男性における黒酵母の2つの新規菌株が産生するβ1,3-1,6グルカンの免疫および代謝への有益性 探索的研究
https://www.medrxiv.org/content/10.1101/2021.08.05.21261640v1

3)
Ikewaki N, Onaka T, Ikeue Y, Nagataki M, Kurosawa G, Dedeepiya VD, Rajmohan M, Vaddi S, Senthilkumar R, Preethy S, Abraham SJK. Beneficial effects of the AFO-202 and N-163 strains of Aureobasidium pullulans produced 1,3-1,6 beta glucans on non-esterified fatty acid levels in obese diabetic KKAy mice: A comparative study.
黒酵母が生産する1,3-1,6β-グルカンの新規菌株が糖尿病性KKAyマウスの非エステル化脂肪酸レベルに及ぼす有益性
https://www.biorxiv.org/content/10.1101/2021.07.22.453362v3

2)
Ikewaki N, Kurosawa G, Iwasaki M, Preethy S, Dedeepiya VD, Vaddi S, Senthilkumar R, Levy GA, Abraham SJK. Hepatoprotective effects of Aureobasidium pullulans derived Beta 1,3-1,6 biological response modifier glucans in a STAM- animal model of non-alcoholic steatohepatitis .
非アルコール性脂肪肝炎のSTAM動物モデルにおける黒酵母由来のβ1,3-1,6 biological response modifier glucansの肝保護作用に関する研究
https://www.biorxiv.org/content/10.1101/2021.07.08.451700v1

1)
Raghavan K, Dedeepiya VD, Kandaswamy R, Balamurugan M, Ikewaki N, Sonoda T, Kurosawa K, Iwasaki M, Preethy S, Abraham SJK. Improvement of sleep patterns and serum melatonin levels in children with autism spectrum disorders after consumption of beta-1,3/1,6-glucan in a pilot clinical study.
β-1,3/1,6-グルカン摂取による自閉症スペクトラム児の睡眠パターンおよび血清メラトニン濃度の改善に関するパイロット臨床研究
https://www.researchsquare.com/article/rs-701988/v1

ジャーナル掲載論文

2022-01:
Raghavan K, Dedeepiya VD, Ikewaki N, Sonoda T, Iwasaki M, Preethy S, Abraham SJK. Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomized, parallel-group pilot clinical study. BMJ Neurology Open
自閉症スペクトラム障害におけるβグルカン食品の摂取による行動パターンおよびαシヌクレインレベルの改善に関する無作為化並行群間パイロット臨床研究
http://dx.doi.org/10.1136/bmjno-2021-000203

2021-05:
Ikewaki N, Raghavan K, Dedeepiya VD, Suryaprakash V, Iwasaki M, Preethy S, senthilkumar R, Abraham SJK.Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats. Clinical Immunology Communications 2021.
黒酵母菌株AFO-202およびN-163が産生するβグルカンのSprague Dawleyラットにおける有益な免疫制御作用
https://www.sciencedirect.com/science/article/pii/S2772613421000081?via%3Dihub

2021-04:
Ikewaki N, Dedeepiya VD, Raghavan K, Rao K, Vaddi S, Osawa H, Kisaka T, Kurosawa G, Srinivasan S, Ganesakumar SRB, Senthilkumar R, Iwasaki M, Preethy S, Abraham SJK. β‑glucan vaccine adjuvant approach for cancer treatment through immune enhancement (B‑VACCIEN) in specific immunocompromised populations (Review). Oncol Rep 47: 14, 2022 doi.org/10.3892/or.2021.8225
特定の免疫不全集団におけるβグルカンのワクチンアジュバント・アプローチによる免疫強化を通じた癌治療(B-VACCIEN)(レビュー)
https://www.spandidos-publications.com/10.3892/or.2021.8225

2021-03:
Raghavan K, Dedeepiya VD, Suryaprakash V, Rao KS, Ikewaki N, Sonoda T, Levy GA, Iwasaki M, Senthilkumar R, Preethy S, Abraham SJK. Beneficial Effects of novel Aureobasidium Pullulans strains produced Beta-1,3-1,6 Glucans on Interleukin-6 and D-Dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study. Biomedicine & Pharmacotherapy, Article 112243, doi: 10.1101/2021.08.09.21261738
COVID-19(新型コロナウィルス感染症)患者のIL-6およびD-ダイマー値に対する新規黒酵母菌株産生のβ-1,3-1,6グルカンの有益性;無作為化多群試験の結果
https://www.medrxiv.org/content/10.1101/2021.08.09.21261738v1

2021-02:
Ikewaki N, Iwasaki M, Kurosawa G, Rao KS, Beitia JL, Preethy S, Abraham SJK. β-Glucans: Wide-spectrum Immune-balancing Food-supplement-based Enteric (β-WIFE) Vaccine Adjuvant Approach to COVID-19. Human Vaccines & Immunotherapeutics 2021; 17(9). doi:10.1080/21645515.2021.1880210.
特定の免疫不全集団におけるβグルカンのワクチンアジュバント・アプローチによる免疫強化を通じた癌治療(B-VACCIEN)(レビュー)
https://www.spandidos-publications.com/10.3892/or.2021.8225

2021-01:
Ikewaki N, Dedeepiya VD, Iwasaki M, Abraham SJK. General Commentary: Beyond “TRIM” benefits of β-glucan by blood glucose and lipid balancing potentials in its defense Against COVID-19. doi: 10.3389/fimmu.2021.620658
黒酵母菌株AFO-202およびN-163が産生するβグルカンのSprague Dawleyラットにおける有益な免疫制御作用
https://www.sciencedirect.com/science/article/pii/S2772613421000081?via%3Dihub

2020-03:
Rao K-S, Suryaprakash V, Senthilkumar R, Preethy S, Katoh S, Ikewaki N, Abraham SJK. Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements. Front. Immunol. 2020; 11:1548. doi: 10.3389/fimmu.2020.01548.
特定のCOVID-19(新型コロナウィルス感染症)患者の死亡率上昇における免疫調節の役割と、栄養補助食品による免疫強化の戦略
https://www.frontiersin.org/articles/10.3389/fimmu.2020.01548/full

2020-02:
Ikewaki N, Rao KS, Archibold AD, Iwasaki M, Senthilkumar R, Preethy S, Katoh S, Abraham SJK. Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a Biological Response Modifier Glucan. Thromb J. 2020. doi: 10.1186/s12959-020-00239-6
COVID-19(新型コロナウィルス感染症)に伴う血液凝固異常-生物学的応答調節物質グルカンを用いた展望と予防策
https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-020-00239-6

2020-01:
Ikewaki N, Iwasaki M, Abraham SJK. Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients. Journal of Diabetes & Metabolic Disorders 2020. doi: 10.1007/s40200-020-00664-4
COVID-19(新型コロナウィルス感染症)患者における、血糖値のバランスを調整する生物学的応答調節物質グルカンによる予防の可能性
https://link.springer.com/article/10.1007/s40200-020-00664-4

2014-01:
Ikewaki N, Iwasaki M, Abraham SJK. Beneficial effects of Black yeast derived 1-3, 1-6 beta glucan- Nichi Glucan in a dyslipidemic individual of Indian origin A case report. J Diet Suppl. 2014;11(1):1-6. doi:10.3109/19390211.2013.859211.
インド人脂質異常症患者における黒酵母由来1-3, 1-6βグルカン-ニチグルカンの有用性ー症例報告
https://www.tandfonline.com/doi/full/10.3109/19390211.2013.859211

2012-01:
Dedeepiya V, Sivaraman G,Venkatesh A, Preethy S, Abraham SJK. Potential Effects of Nichi Glucan as a Food Supplement for Diabetes Mellitus and Hyperlipidemia; Preliminary Findings from the Study on Three Patients from India. Case Reports in Medicine 2012 (2012), Article ID 895370;. doi:10.1155/2012/895370.
糖尿病および高脂血症に対するNichi Glucanの食品としての可能性
https://www.hindawi.com/journals/crim/2012/895370/