ニチグルカン関連 論文



2022-10:(AFO-202)Med Princ Pract

Preethy S, Raghavan K, Ikewaki N, Abraham SJ. 
Qualitative Evaluation of α-Synuclein – A Critical Step in Unraveling the Complexities of Autism Spectrum Disorder. 
α-シヌクレインの定性的評価 – 複雑な自閉症スペクトラムの解明への重要なステップ

2022-09:(AFO-202, N-163)BMJ Open Gastroenterology

Preethy S, Ikewaki N, Levy GA, Raghavan K, Dedeepiya VD, Yamamoto N, Srinivasan S, Ranganathan N, Iwasaki M, Senthilkumar R, Abraham SJK. 
Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential for applications in human health and disease. 

2022-08:(AFO-202, N-163)Frontiers in Immunology

Preethy S, Raghavan K, Dedeepiya VD, Suryaprakash V, Ikewaki N, Ikeue Y, Nagataki M, Iwasaki M, Senthilkumar R, Abraham S. 
Beneficial immune regulation by biological response modifier glucans in COVID-19 and their envisaged potentials in the management of sepsis.

2022-07:(AFO-202)Journal of Alzheimer’s Disease

Preethy S, Ranganathan N, Raghavan K, Dedeepiya VD, Ikewaki N, Abraham S.
Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders

2022-06:(AFO-202)Journal of Food Biochemistry

Ikewaki, N., Kurosawa, G., Kisaka, T. and Abraham, S.J.K. (2022), 
Controlled modulation of all the arms of the immunity including innate immunity by biological response modifier glucans, a simple yet potential nutritional supplement strategy to fight COVID-19. 

2022-05:(AFO-202)Journal of Alzheimer’s disease

Raghavan K, Dedeepiya VD, Yamamoto N, Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M,Kandaswamy R, Senthilkumar R, Preethy S, Abraham SJK. 
Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases

2022-04: (AFO-202, N-163)  Journal of Diabetes and Metabolic Disorders

Ikewaki N, Onaka T, Ikeue Y, Nagataki M, Kurosawa G, Dedeepiya VD, Rajmohan M, Vaddi S, Senthilkumar R, Preethy S, Abraham SJK. 
Beneficial effects of 1,3–1,6 β-glucans produced by Aureobasidium pullulans on non-esterified fatty acid levels in diabetic KKAy mice and their potential implications in metabolic dysregulation
黒酵母が生産する 1,3-1,6 βグルカンの糖尿病性 KKAy マウスの非エステル化脂肪酸レベルに対する有益な効果と代謝異常への潜在的な影響について

2022-03: (AFO-202, N-163)  Brain and Behavior

Raghavan K, Dedeepiya VD, Kandaswamy R, Balamurugan M, Ikewaki N, Sonoda T, Kurosawa K, Iwasaki M, Preethy S, Abraham SJK. 
Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study

2022-02: (AFO-202, N-163)Journal of Clinical and Experimental Hepatology

Nobunao Ikewaki, Gary A. Levy, Gene Kurosawa, Masaru Iwasaki, Vidyasagar D. Dedeepiya, Suryaprakash Vaddi
Rajappa Senthilkumar, Senthilkumar Preethy, Samuel J.K. Abraham 
Hepatoprotective Effects of Aureobasidium pullulans Derived β 1,3–1,6 Glucans in a Murine Model of Non-alcoholic Steatohepatitis
非アルコール性脂肪肝炎のSTAM動物モデルにおける黒酵母由来のβ1,3-1,6 biological response modifier glucansの肝保護作用に関する研究

2022-01: (AFO-202)  BMJ Neurology Open

Raghavan K, Dedeepiya VD, Ikewaki N, Sonoda T, Iwasaki M, Preethy S, Abraham SJK. 
Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomized, parallel-group pilot clinical study. 

2021-05: (AFO-202, N-163)  Clinical Immunology Communications

Ikewaki N, Raghavan K, Dedeepiya VD, Suryaprakash V, Iwasaki M, Preethy S, senthilkumar R, Abraham SJK.
Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats
黒酵母菌株AFO-202およびN-163が産生するβグルカンのSprague Dawleyラットにおける有益な免疫制御作用

2021-04: (AFO-202)  Oncology Reports

Ikewaki N, Dedeepiya VD, Raghavan K, Rao K, Vaddi S, Osawa H, Kisaka T, Kurosawa G, Srinivasan S, Ganesakumar SRB, Senthilkumar R, Iwasaki M, Preethy S, Abraham SJK. 
β‑glucan vaccine adjuvant approach for cancer treatment through immune enhancement (B‑VACCIEN) in specific immunocompromised populations (Review)

2021-03: (AFO-202, N-163)  Biomedicine & Pharmacotherapy

Raghavan K, Dedeepiya VD, Suryaprakash V, Rao KS, Ikewaki N, Sonoda T, Levy GA, Iwasaki M, Senthilkumar R, Preethy S, Abraham SJK. 
Beneficial Effects of novel Aureobasidium Pullulans strains produced Beta-1,3-1,6 Glucans on Interleukin-6 and D-Dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study

2021-02: (AFO-202)  Human Vaccines & Immunotherapeutics

Ikewaki N, Iwasaki M, Kurosawa G, Rao KS, Beitia JL, Preethy S, Abraham SJK. 
β-Glucans: Wide-spectrum Immune-balancing Food-supplement-based Enteric (β-WIFE) Vaccine Adjuvant Approach to COVID-19 

2021-01: (AFO-202)  Frontiers in Immunology

Ikewaki N, Dedeepiya VD, Iwasaki M, Abraham SJK. 
Commentary: Beyond “TRIM” benefits of β-glucan by blood glucose and lipid balancing potentials in its defense Against COVID-19

2020-03: (AFO-202)  Frontiers in Immunology

Rao K-S, Suryaprakash V, Senthilkumar R, Preethy S, Katoh S, Ikewaki N, Abraham SJK. 
Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements

 2020-02: (AFO-202)  Thrombosis Journal

Ikewaki N, Rao KS, Archibold AD, Iwasaki M, Senthilkumar R, Preethy S, Katoh S, Abraham SJK. 
Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a Biological Response Modifier Glucan.

2020-01: (AFO-202)  Journal of Diabetes & Metabolic Disorders volume

Ikewaki N, Iwasaki M, Abraham SJK. 
Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients.

2014-01: (AFO-202)  Journal of Dietary Supplement

Ikewaki N, Iwasaki M, Abraham SJK.
Beneficial effects of Black yeast derived 1-3, 1-6 beta glucan- Nichi Glucan in a dyslipidemic individual of Indian origin A case report. J Diet Suppl.
インド人脂質異常症患者における黒酵母由来1-3, 1-6βグルカン-ニチグルカンの有用性ー症例報告

2012-01: (AFO-202)  Case Reports in Medicine

Dedeepiya V, Sivaraman G,Venkatesh A, Preethy S, Abraham SJK.
Potential Effects of Nichi Glucan as a Food Supplement for Diabetes Mellitus and Hyperlipidemia; Preliminary Findings from the Study on Three Patients from India.
糖尿病および高脂血症に対するNichi Glucanの食品としての可能性


5) (N-163)

Raghavan K, Dedeepiya VD, Yamamoto N, Ikewaki N, Iwasaki M, Dinassing A, Senthilkumar R, Preethy S, Abraham SJK. 
Randomised trial of Aureobasidium pullulans-produced beta 1,3-1,6-glucans in patients with Duchenne muscular dystrophy: Favourable changes in gut microbiota and clinical outcomes indicating their potential in epigenetic manipulation. 
デュシェンヌ型筋ジストロフィー患者を対象としたAureobasidium pullulans産β1,3-1,6-glucansの無作為化試験:腸内細菌叢の好ましい変化とエピジェネティックな操作の可能性を示す臨床結果

4)  (N-163)

Preethy S, Aoki Y, Minegishi K, Senthilkumar R, Abraham S. 
Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced biological response modifier β-glucan (BRMG). 
Aureobasidium pullulansのN-163株の生物学的応答修飾物質βグルカン(BRMG)経口摂取によるmdxジストロフィーマウスの線維化解消の検討

3)  (AFO-202, N-163)

Pushkala S, Seshayyan S, Theranirajan E, Sudhakar D, Raghavan K, Dedeepiya VD, Ikewaki N,Iwasaki M, Preethy S, Abraham S.
Efficient control of IL-6, CRP and Ferritin in Covid-19 patients with two variants of Beta-1,3-1,6 glucans in combination, within 15 days in an open-label prospective clinical trial. 

2) (N-163)

Raghavan K, Dedeepiya VD, Srinivasan S, Pushkala S, Subramanian S, Ikewaki N, Iwasaki M, Senthilkumar R, Preethy S, Abraham S. 
Disease-modifying immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in young boys with Duchenne muscular dystrophy: Results of an open-label, prospective, randomized, comparative clinical study
Duchenne型筋ジストロフィーの少年におけるAureobasidium pullulans産の1,3-1,6βグルカンN-163株の疾患修飾免疫調節効果。非盲検前向き無作為化比較臨床試験結果

1)(AFO-202, N-163)

Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M, Dedeepiya VD, Senthilkumar R, Preethy S, Abraham SJK. 
Immune and metabolic beneficial effects of Beta 1,3-1,6 glucans produced by two novel strains of Aureobasidium pullulans in healthy middle-aged Japanese men: An exploratory study
健康な日本人中年男性における黒酵母の2つの新規菌株が産生するβ1,3-1,6グルカンの免疫および代謝への有益性 探索的研究

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