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Beta-glucan is a polysaccharide consisting of glucose bound together in a beta structure. It is known to be found in shiitake mushrooms and yeast.

There is a type of beta-glucan called beta-1, 3-1, 6-glucan which is said to be beneficial for the immune system.

Beta-1, 3-1, 6-glucan
[Chemical name] beta-1,3-1,6-D-glucan [Molecular structure] (C6H10O5)n


In the case of shiitake mushrooms, beta-1, 3-1, 6-glucan must be extracted and purified, but this is not necessary with black yeast as it is produced outside the body. By cultivating the black yeast fungus, beta-1, 3-1, 6-glucan can be produced efficiently.


The black yeast fungus produces beta-1, 3-1, 6-glucan outside its cells. After production, the culture medium is heat sterilized, so there are no live bacteria.

NICHI GLUCAN is an Aureobasidium culture that has been approved as a food additive in Japan. (Aureobasidium = black yeast)

Different strains of black yeast produce beta-1, 3-1, 6-glucan with completely different molecular structures. NICHI GLUCAN uses the AFO-202 strain as its seed. NICHI GLUCAN is also water-soluble and can be added to other foods such as soups.

The molecular structure of β-1, 3-1, 6-glucan produced by strain AFO-202 is called BRMG.
BRMG is a combination of the medical term BRM (Biological Response Modifier) and G (Glucan).

The amount of BRMG in NICHI GLUCAN is 42mg in 1g (1 sachet).

One box is a one-month supply, but most people take one to three sachets a day, depending on their health.
Those who are under medication should consult their physician before consumption.

Nichi Glucan range of products are approved as a food additive/food supplement in Japan. They are produced as an exo-polysaccharide by Black yeast Aureobasidium Pullulans in GMP certified facility in Japan and sold in different brands based on the strain of produce, dosage etc. These products are not drug or cure to any illness and approval status vary between countries. The manufacturer and/or exporters don’t give any medical advice as these products are not having any therapeutic claims. The pre-clinical and clinical study reports published are meant for educational and research initiative purposes. Those who have clarifications, may please consult their physician.

Common purchase queries answered

Orders and Shipping

We usually ship within 3 business days. We will contact you if there is a delay in shipping due to stock shortage or other reasons.

Please go to the Account page in the upper right corner and fill out the required information to register.

Please contact us using the contact form.
Please note that changes cannot be made after shipment.

We will send you order and shipping information via email.
If you have any questions, please contact us by email.

We use PayPal and Stripe and do not keep your credit card information on file with us.

NICHI GLUCAN is a food product and is subject to an 8% consumption tax.

International shipping is possible, but you will need to check shipping costs and import requirements of the destination country. Please contact us by email.

Up to 12 boxes can be shipped in one package.

If you need to swap an item

Returns and Exchanges

For all “orders”, “deliveries”, “returns” and “exchanges”, please contact our customer service.

As a general rule, we accept returns and exchanges within 7 days of receipt of the product for domestic delivery. For overseas delivery, we will inform you of the conditions at the time of quotation.
We do not accept returns or exchanges for customer reasons. If you would like to return or exchange an item due to a defect or problem, please contact us using the contact form.

Please contact us using the contact form.

Please contact us using the contact form.

We will tell you when you contact us via contact form.

Please contact us using the contact form.

Please contact us using the contact form.
Please note that we cannot change the address after the order has been shipped.

If you wish to change or cancel your order before it is shipped, please contact us using the contact form.
No changes or cancellations will be accepted after shipment.

Yes, you can. Please contact us using the contact form.